Table 2.

Histological and immunohistochemical characteristics of pyloric gland adenomas in familial adenomatous polyposis.

Patient	Dx	Dysplasia	Size (mm)	location	Parietal cells	β-catenin	P53	Ki67	MUC2	MUC5	MUC6	CDX2
1	PGA1*	LGD	U	U	None	M	np	mild increase	np	surface pos	failed	neg
1	PGA2	LGD	17	corpus	scattered	M	np	not increased	neg	surface pos	focal pos	focal pos
2	PGA3	Focal HGD	15	corpus or fundus	Many	Focal nuclear in HGD	WT	Increased in HGD	neg	surface pos	pos	focal pos
2	PGA4	LGD	8	corpus	scattered	M	WT	Focally increased	neg	surface pos	pos	focal pos
3	PGA5	LGD	40	corpus	Scattered and focally abundant	M	WT	not increased	neg	surface pos	focal pos	neg
3	PGA6	LGD	13	corpus	scattered	np	np	np	np	surface pos	pos	np
3	PGA7	LGD	U	corpus or fundus	scattered	np	np	np	np	surface pos	pos	np

Dx: diagnosis; PGA: pyloric gland adenoma; LGD: low-grade dysplasia; IGD: intermediate grade dysplasia; HGD: high-grade dysplasia; M: membranous β-catenin expression; WT: wild-type expression of p53; neg: negative staining; pos: positive staining; np: not performed; U: unknown.

^*This was a very small biopsy of a PGA and therefore suboptimal for histopathological assessment.