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Time dependence of PGE2 production in 3D organotypic skin cultures after 2 Gy irradiation (A) and effect of COX-2 inhibitor (5 µmol/l sc-236) on the secretion of PGE2 (B). The PGE-2 levels were measured at 0, 24, 48, and 72 h postirradiation. ***p < 0.001, one-way ANOVA analysis, Tukey posttest.
