Table 2.
SNPs within loci associated with protein aggregation recognized as PD susceptibility factors by GWASs.
| Gene/locus Chromosome | SNP | MAF (1000 genomes project) | Risk allele: OR | Study |
|---|---|---|---|---|
| SNCA Ch 4 | rs356182 g.90626111G>A (intron variant) | G = 0.4044 | G: OR = 1.32 | Nalls et al., 2014 |
| rs356219 g.90637601G>A (intron variant) | A = 0.4892 | OR = 1.29 | Lill et al., 2012 | |
| G: OR = 1.29 | Nalls et al., 2011 | |||
| rs356220 g.90641340T>C (intron variant) | C = 0.4834 | OR = 1.38 | Pankratz et al., 2012 | |
| T: OR = 1.29 | Do et al., 2011 | |||
| T: OR = 1.27 | Spencer et al., 2011 | |||
| T: OR = 1.38 | Hamza et al., 2010 | |||
| T: OR = 1.38 | Hill-Burns et al., 2014 | |||
| T: OR = 1.37 | Saad et al., 2011 | |||
| rs11931074 g.90639515G>T (intron variant) | T = 0.3806 | OR = 1.37 | Satake et al., 2009 | |
| rs2736990 g.90678541G>A c.307-28113C>T (intron variant) | A = 0.3934 | G: OR = 1.23 | Simon-Sanchez et al., 2009 | |
| OR = 1.29 | Edwards et al., 2010 | |||
| rs6532194 g.90780902C>T (intergenic variant) | T = 0.3694 | OR = 1.29 | Lill et al., 2012 | |
| MAPT Ch 8 | rs17649553 g.43994648C>T (intron variant) | T = 0.0865 | C: OR = 1.3 | Nalls et al., 2014 |
| 900 kb inversion | H1/H2 | Lill et al., 2012 | ||
| rs2942168 g.43714850C>T (intron variant) | A = 0.0863 | G: OR = 1.27 | Nalls et al., 2011 | |
| rs393152 g.43719143A>G (intron variant) | G = 0.2476 | A: OR = 1.3 | Simon-Sanchez et al., 2009 | |
| rs12185268 g.43923683A>G p.Ile471Val (missense variant) | G = 0.0863 | A: OR = 1.3 | Do et al., 2011 | |
| rs8070723 g.44081064A>G c.1828-6612A>G (intron variant) | G = 0.1190 | OR = 1.3 | Spencer et al., 2011 | |
| rs17577094 g.44187492A>G c.1290-15425T>C (intron variant) | G = 0.0865 | OR = 1.56 | Vacic et al., 2014 | |
| rs11012 g.43513441C>T c.*1783G>A | T = 0.0807 | T: OR = 1.43 | Edwards et al., 2010 | |
| rs199498 g.46788237T>C c.81-14328A>G (intron variant) | C = 0.2578 | T: OR = 1.35 | Hill-Burns et al., 2014 | |
| rs199533 g.44828931G>A p.Lys702 = (synonimous variant) | A = 0.0791 | C: OR = 1.35 | Hamza et al., 2010 |