Table 3.
SNPs within loci associated with protein and membrane trafficking recognized as PD susceptibility factors by GWASs.
| Gene/locus | SNP | MAF (1000 genomes project) | Risk allele: OR | Study |
|---|---|---|---|---|
| TMEM175/GAK/DGKQ Ch 4 | rs34311866 g.951947T>C p.Met311Thr (missense variant) | C = 0.1400 | C: OR = 1.27 | Nalls et al., 2014 |
| rs11248060 g.964359C>T (intron variant) | T = 0.1066 | OR = 1.21 | Lill et al., 2012 | |
| OR = 1.26 | Pankratz et al., 2012 | |||
| NA | Edwards et al., 2010 | |||
| rs6599388 g.939087C>T (intron variant) | T = 0.3243 | T: OR = 1.16 | Nalls et al., 2011 | |
| rs11248051 g.858332C>T (intron variant) | T = 0.0966 | T: OR = 1.46 | Hamza et al., 2010 | |
| rs6599389 g.939113G>A (intron variant) | A = 0.1092 | A: OR = 1.31 | Do et al., 2011 | |
| NUCKS1/RAB7L1 Ch 1 | rs823118 g.205723572C>T (upstream gene variant) | T = 0.4111 | T: OR = 1.122 | Nalls et al., 2014 |
| rs947211 g.205752665A>G (intergenic variant) | A = 0.4613 | OR = 1.3 | Satake et al., 2009 | |
| rs823128 g.205713378G>A (intron variant) | G = 0.1765 | A: OR = 1.52 | Simon-Sanchez et al., 2009 | |
| rs823114 g.205719532G>A c.-431C>T (upstream gene variant) | A = 0.4073 | OR = 1.33 | Vacic et al., 2014 | |
| LRRK2 Ch 12 | rs76904798 g.40614434C>T (intron variant) | T = 0.1318 | T: OR = 1.155 | Nalls et al., 2014 |
| rs34637584 g.40734202G>A p.Gly2019Ser (missense variant) | A = 0.0002 | A: OR = 9.62 | Do et al., 2011 | |
| rs1442190 g.41365640G>A c.*325G>A | A = 0.0747 | OR = 3.72 | Vacic et al., 2014 | |
| rs34778348 g.40757328G>A p.Gly2385Arg (missense variant) | A = 0.0048 | OR = 2.23 | Lill et al., 2012 | |
| rs1491942 g.40620808C>G c.237+1366C>G (intron variant) | G = 0.2979 | OR = 1.17 | Lill et al., 2012 | |
| G: OR = 1.27 | Nalls et al., 2011 | |||
| rs1994090 g.40428561G>T c.717-6250C>A (intron variant) | G = 0.1472 | OR = 1.39 | Satake et al., 2009 | |
| INPP5F Ch 10 | rs117896735 g.121536327G>A c.179-4820G>A (intron variant) | A = 0.0040 | A: OR = 1.624 | Nalls et al., 2014 |
| BCKDK/STX1B Ch 16 | rs14235 g.31110472G>A c.615G>A p.Thr205 = (synonymous variant) | A = 0.3592 | A: OR = 1.103 | Nalls et al., 2014 |
| VPS13C Ch 15 | rs2414739 g.61701935G>A (intron variant) | G = 0.3209 | A: OR = 1.113 | Nalls et al., 2014 |