Table 4.
SNPs within loci associated with lysosomal autophagy recognized as PD susceptibility factors by GWASs.
| Gene/locus | SNP | MAF (1000 genomes project) | Risk allele: OR | Study |
|---|---|---|---|---|
| GBA/SYT11 Ch 1 | rs35749011 g.155135036G>A (intergenic variant) | A = 0.0054 | A: OR = 1.824 | Nalls et al., 2014 |
| i4000416 g.155205634T>C c.1226A>C p.Asn409Ser (missense variant) | C = 0.0006 | C: OR = 4.05 | Do et al., 2011 | |
| rs1630500 g.154855055G>A (intergenic variant) | A = 0.0559 | OR = 1.75 | Vacic et al., 2014 | |
| rs12726330 g.155108167G>A c.-262G>A (splice region variant) | A = 0.0052 | OR = 1.71 | Pankratz et al., 2012 | |
| rs34372695 g.156030037C>T c.-1155C>T (upstream gene variant) | T = 0.0088 | T: OR = 1.47 | Nalls et al., 2011 | |
| SCARB2/FAM47E Ch 4 | rs6812193 g.77198986C>T c.871-236C>T (intron variant) | T = 0.3133 | C: OR = 1.1 | Nalls et al., 2014 |
| C: OR = 1.19 | Do et al., 2011 | |||
| C: OR = 1.12 | Simon-Sanchez et al., 2009 |