Table 5.
SNPs within loci associated with immune system recognized as PD susceptibility factors by GWASs.
| Gene/locus | SNP | MAF (1000 genomes project) | Risk allele: OR | Study |
|---|---|---|---|---|
| BST1 Ch 4 | rs11724635 g.15737101C>A (intron variant) | A = 0.4079 | A: OR = 1.126 | Nalls et al., 2014 |
| A: OR = 1.15 | Nalls et al., 2011 | |||
| rs4538475 g.15737937A>G c.*195A>G (intron variant) | G = 0.3089 | OR = 1.24 | Satake et al., 2009 | |
| rs4698412 g.15737348G>A c.852-328G>A (intron variant) | A = 0.4077 | OR = 1.14 | Pankratz et al., 2012 | |
| A: OR = 1.14 | Saad et al., 2011 | |||
| STK39 Ch 2 | rs1474055 g.169110394C>T (intergenic variant) | T = 0.2007 | T: OR = 1.214 | Nalls et al., 2014 |
| rs2102808 g.169117025G>T (intergenic variant) | T = 0.2083 | C: OR = 1.18 | Nalls et al., 2011 | |
| HLA-DQB1 Ch 6 | rs9275326 g.32666660C>T (intergenic variant) | T = 0.0843 | C: OR = 1.21 | Nalls et al., 2014 |
| DDRGK1 Ch 20 | rs8118008 g.3168166A>G (downstream gene variant) | G = 0.4597 | A: OR = 1.111 | Nalls et al., 2014 |