Table 6.
SNPs within loci associated with neurodevelopment, neuron cell differentiation and survival recognized as PD susceptibility factors by GWASs.
| Gene/locus | SNP | MAF (1000 genomes project) | Risk allele: OR | Study |
|---|---|---|---|---|
| CCDC62 Ch 12 | rs11060180 g.123303586A>G c.2002-4327A>G (intron variant) | G = 0.2516 | A: OR = 1.105 | Nalls et al., 2014 |
| rs12817488 g.123296294G>A c.1852-1523G>A (intron variant) | A = 0.4159 | T: OR = 1.14 | Nalls et al., 2011 | |
| RIT2 Ch 18 | rs12456492 g.43093415A>G c.103+22002T>C (intron variant) | G = 0.3297 | G: OR = 1.11 | Nalls et al., 2014 |
| OR = 1.19 | Pankratz et al., 2012 | |||
| rs4130047 g.43098270T>C c.103+17147A>G (intron variant) | C = 0.3237 | C: OR = 1.16 | Do et al., 2011 | |
| FGF20 Ch 8 | rs591323 g.16697091G>A (intron variant) | A = 0.3652 | G: OR = 1.09 | Nalls et al., 2014 |
| GCH1 Ch 14 | rs11158026 g.55348869C>T c.344-16715G>A (intron variant) | C = 0.4898 | C: OR = 1.11 | Nalls et al., 2014 |
| GPNMB Ch 2 | rs199347 g.23293746A>G c.224-42A>G (intron variant) | A = 0.4832 | A: OR = 1.11 | Nalls et al., 2014 |