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. 2017 Feb 10;8:53. doi: 10.3389/fphar.2017.00053

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Copyright © 2017 Pereira, Mendes, Pereira, Muniz, Colares, Monteiro, Martins, Grisotto, Monteiro-Neto, Monteiro, Calixto, Brain and Fernandes.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Visual analog scale (VAS) pain scale, (B) HAQ-DI, and (C) TRPA1 expression on peripheral blood leukocytes in patients with rheumatoid arthritis (RA) treated or not with either leflunomide (LFN; n = 15) or adalimumab (ADA; n = 15), in comparison with patients recently diagnosed with RA but not yet receiving specific treatment with anti-rheumatic drugs (NST group; n = 10) and healthy subjects (n = 15). Data are expressed as mean ± SD. (D) Scatter plot for TRPA1 correlation with VAS pain scale and HAQ-DI. ^∗p < 0.05, differs from healthy subjects; ^#p < 0.05, differs from the NST group.