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Systemic (A) 4-HNE and (B) H2O2 levels in patients with RA treated or not with either leflunomide (LFN; n = 15) or adalimumab (ADA; n = 15), in comparison with patients recently diagnosed with RA but not yet receiving specific treatment with anti-rheumatic drugs (NST group; n = 10) and healthy subjects (n = 15). Data are expressed as mean ± SD. ∗p < 0.05, differs from healthy subjects; #p < 0.05, differs from the NST group.
