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. 2017 Jan 6;7(1):e513. doi: 10.1038/bcj.2016.121

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(a–c) High DDR1 gene expression correlates with a shorter time-to-treatment in CLL in three public-access data sets. Cut-off was median DDR1 value in a and b. In c the best cut-off point for DDR1 gene expression discriminating cases with immunoglobulin variable heavy (IGVH) mutated from those unmutated was sought by constructing receiver operating character (ROC) analysis. Curves were constructed using the Kaplan–Meier method and compared with the Wilcoxon log-rank test. (d, e) DDR1 gene expression is higher in CLL with unmutated IGVH relative to mutated cases (d) and in ZAP70-positive cases relative to negative ones (e) (mean±s.e.m.).