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. 2017 Jan 6;7(1):e516. doi: 10.1038/bcj.2016.122

Figure 3.

Figure 3

Distributions of TET2/DNMT3A/RHOA/IDH2/NOTCH1 mutations and IgH VDJ status. Allele frequencies of TET2/DNMT3A/RHOA/IDH2/NOTCH1 mutations in whole tumor, PD1+ cells and CD20+ cells are shown. The blue boxes represent positive TET2 mutations; the green boxes, positive DNMT3A mutations; the red boxes, positive RHOA mutations; the orange boxes, positive IDH2 mutations; the purple boxes, positive NOTCH1 mutations; the yellow boxes, no mutations; and the white boxes, not examined. The numeric values indicate allele frequencies of mutations defined by deep sequencing, except for that in the box surrounded by bold red lines which was estimated by Sanger sequencing. IgH VDJ status indicates the IgH VDJ rearrangement status in whole-tumor-derived DNA. The AITL samples are indicated in black letters. The nodal PTCL with TFH phenotype sample is indicated in red letters. The PTCL-NOS/nodal PTCL with TFH phenotype sample is indicated in blue letters. MC, monoclonality; OC, oligoclonality; Pos: positivity was evaluated only by Sanger sequencing. Multiple TET2 mutations were identified in PTLC2, 8, 60, 63, 77, 136, 121, 123, 127 and 129.