Table 3. VDJ rearrangement status of B-cell clones in B-cell-specific mutated samples.
| Sample | Diagnosis | Number of colonies having the identical VDJ gene usage/total number of colonies analyzed | Common VDJ gene usage | Identity of V gene (%) | Amino-acid sequences of junctions |
|---|---|---|---|---|---|
| PTCL63 | AITL | 2/12 | V3-21/D2-2/J5 | 72.2 | CARSTQTYYQLLWNG#NWFDPWa |
| PTCL74 | AITL | NAb | V1-2/J1 or J2 or J3 | 84.4 | Not identified at http://www.imgt.org |
| PTCL78 | AITL | 2/12 | V3-23/J6/D4-17 | 72.2 | CAKGNDYGDSYYYGMDVW |
| 2/12 | V3/J6/D3-10 | 77.2 | CARDRGYYYYGMDVW | ||
| PTCL126 | PTCL-NOS/nodal PTCL with TFH phenotype | 2/12 | V6-1/J6/D3-3 | 71.0 | CARTTPSTIFGVVTAGYYYYGMDVW |
a
Out of frame junction.
b
NA, not applicable because direct sequencing demonstrated monoclonality.