Table 1.
A. Association with MS | |||||
---|---|---|---|---|---|
| |||||
Gene | 5′ to CCL11 | 3′ to CCL14 | Nonsyn CCL14 | ||
|
|
|
|
||
Marker | PG13 | PG28 | PG29 | ||
MS–control | χ2 | 4.34 | 4.89 | 4.23 | |
P | 0.037 | 0.027 | 0.04 | ||
↑Allele | T(T/C) | A(C/A) | T(T/C) | ||
Freq. in controls/MS | 0.850/0.882 | 0.221/0.267 | 0.936/0.958 | ||
B. Association with SLE | |||||
| |||||
Gene | Nonsyn CCL11 | 3′ to CCL14 | Nonsyn CCL15 | 5′ to CCL3 | |
|
|
|
|
|
|
Marker | PG14 | PG28 | PG38 | PG46 | |
| |||||
SLE–control | χ2 | 3.96 | 33.65 | 5.26 | 4.01 |
P | 0.047 | 6.59−9 | 0.022 | 0.045 | |
↑Allele | G(G/A) | A(C/A) | T(C/T) | G(G/T) | |
Freq. in controls/SLE | 0.818/0.881 | 0.221/0.460 | 0.039/0.079 | 0.633/0.713 |
All marker alleles with a p<0.05 are indicated for CCL markers in MS (A) and SLE (B). In the row of alleles, the allele that is increased in the disease is indicated and the major and minor alleles of each SNP, respectively, are shown in parenthesis. After Bonferroni correction, only the A (minor) allele of PG28 shows significant association with SLE.