Table 2.
Marker genotype association with MS and SLE
| A. Association with MS | |||||
|---|---|---|---|---|---|
|
| |||||
| Gene | Nonsyn CCL14 | ||||
|
|
|
||||
| Marker | PG29 | ||||
| MS–control | χ2 | 6.18 | |||
| p | 0.046 | ||||
| Genotype | CC/CT/TT | ||||
| Freq. in controls | 0/0.127/0.873 | ||||
| Freq. in MS | 0.002/0.081/0.917 | ||||
| B. Association with SLE | |||||
|
| |||||
| Gene | 3′ to CCL14 | Nonsyn CCL15 | 5′ to CCL15 | 5′ to CCL15 | |
|
|
|
|
|
|
|
| Marker | PG28 | PG38 | PG39 | PG40 | |
|
| |||||
| SLE–control | χ2 | 36.6 | 6.61 | 6.97 | 6.45 |
| p | <0.0001 | 0.037 | 0.031 | 0.040 | |
| Genotype | AA/AC/CC | CC/CT/TT | AA/AT/TT | CC/CG/GG | |
| Freq. in controls | 0.037/0.368/0.595 | 0.924/0.074/0.002 | 0/0.102/0.898 | 0/0.097/0.903 | |
| Freq. in SLE | 0.127/0.667/0.206 | 0.843/0.157/0 | 0.012/0.151/0.837 | 0.11/0.135/0.854 | |
All SNP genotype associations (p<0.05) with MS (A) and SLE (B) are indicated. After correction for multiple testing, significant deviation only in the PG28 genotype distribution is noted in SLE patients as compared to controls.