Table 3.
Association with SLE | |||||
---|---|---|---|---|---|
| |||||
Gene | Haplotype markers | Haplotype | Haplotype frequency in controls/SLE | SLE–control | |
| |||||
χ2 | P | ||||
3′ to CCL14-nonsyn CCL14 | PG28–PG29 | CT | 0.764/0.600 | 20.68 | 5.44−6 |
AT | 0.173/0.315 | 19.26 | 1.14−5 | ||
3′ to CCL14-5′ to CCL14 | PG28–PG29–PG30–PG31–PG32 | CTAAG | 0.687/0.544 | 13.18 | 3.00−4 |
ATAAG | 0.092/0.188 | 13.88 | 2.00−4 |
Haplotypes of PG28–29 and PG28–29–30–31–32 show significant associations with SLE, while none of the haplotypes are associated with MS (data not shown) after correction for multiple testing. The PG28–29 haplotype defined by the A–T alleles, and the PG28–PG29–PG30–PG31–PG32 haplotype defined by the A–T–A–A–G alleles are increased in SLE.