. Author manuscript; available in PMC: 2017 Feb 10.

Published in final edited form as: J Neuroimmunol. 2008 Jul 3;200(1-2):145–152. doi: 10.1016/j.jneuroim.2008.05.016

Table 4.

Association of CCL haplotypes with severity of MS

Gene	Haplotype markers	Haplotype	Haplotype frequency in: controls/severe MS/mild MS	χ²	P
5′ to CCL8-intron CCL8	PG19–PG22	CG	0.170/0.230/0.112	8.95	0.003
Intron CCL8	PG22–PG23	AT	0.822/0.767/0.890	9.75	0.002
		GC	0.178/0.233/0.110	8.47	0.002
Intron CCL8-synon CCL8	PG23–PG24	TA	0.823/0.777/0.890	8.47	0.004
		CC	0.177/0.223/0.110	8.47	0.004
5′ to CCL8-intron CCL8	PG19–PG22–PG23	CGC	0.175/0.230/0.110	9.37	0.002
Intron CCL8-synon CCL8	PG22–PG23–PG24	ATA	0.825/0.770/0.890	9.38	0.002
		GCC	0.175/0.223/0.110	8.47	0.004

The CGC allele combination of PG19–PG22–PG23 is increased in the severe and decreased in the mild subgroup of MS.