Table 3.
Distribution of main and low channel openings of GABAA receptor
| α1β3γ2L | α1β3γ2L(P302L) | αβa | |||
|---|---|---|---|---|---|
| Main | Low | Main | Low | Low | |
| Number of openings | 9938 | 7086 | 606 | 3929 | 9723 |
| Open probability | 0.555 | 0.619 | 0.077 | 0.149 | 0.680 |
| Mean open time, ms | 9.89 | 14.7 | 16.8 | 5.01 | 2.43 |
| Opening components, ms | |||||
| τO1 (%) | 2.71 (80) | 1.67 (57) | 4.06 (33) | 2.65 (62) | 1.06 (93) |
| τO2 (%) | 14.3 (9) | 8.13 (23) | 20.7 (63) | 4.99 (31) | 6.39 (7) |
| τO3 (%) | 55.3 (11) | 55.8 (20) | 54.5 (4) | 23.9 (7) | NO |
aSingle-channel properties of αβ receptors recorded from cell-attached patches held at +80 mM with 1 mM GABA are shown for comparison. NO, not observed.