Table 1. Baseline characteristics of high-risk and non-high-risk individuals (safety analysis set).
| Characteristic |
Renal impairment of any grade (baseline eGFR<90 ml min−1) |
T2DM |
Hypercholesterolaemia (total cholesterol >240 mg dl−1) |
CV risk factor(s) (T2DM or BMI⩾30 kg m−2 or LDL⩾130 mg dl−1) |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Yes (N=426) | No (N=955) | Yes (N=205) | No (N=1176) | >240 (N=210) | 200–240 (N=454) | <200 (N=715) | 1–3 (N=986) | 1–2 (N=958) | 1 (N=679) | None (N=395) | |
| Age, years, mean | 61.6 | 50.6 | 56.8 | 53.5 | 55.2 | 54.0 | 53.7 | 53.7 | 53.7 | 53.4 | 54.8 |
| Male, n (%) | 232 (54.5%) | 567 (59.4%) | 116 (56.6%) | 683 (58.1%) | 110 (52.4%) | 245 (54.0%) | 442 (61.8%) | 547 (55.5%) | 534 (55.7%) | 390 (57.4%) | 252 (63.8%) |
| Ethnicity | |||||||||||
| White, n (%) | 317 (74.4%) | 685 (71.7%) | 148 (72.2%) | 854 (72.6%) | 166 (79.0%) | 353 (77.8%) | 481 (67.3%) | 730 (74.0%) | 712 (74.3%) | 494 (72.8%) | 272 (68.9%) |
| Black, n (%) | 46 (10.8%) | 180 (18.8%) | 33 (16.1%) | 193 (16.4%) | 25 (11.9%) | 59 (13.0%) | 142 (19.9%) | 180 (18.3%) | 173 (18.1%) | 121 (17.8%) | 46 (11.6%) |
| Asian, n (%) | 55 (12.9%) | 68 (7.1%) | 11 (5.4%) | 112 (9.5%) | 14 (6.7%) | 35 (7.7%) | 74 (10.3%) | 55 (5.6%) | 53 (5.5%) | 48 (7.1%) | 68 (17.2%) |
| BMI, kg m−2, mean | 27.4 | 32.6 | 32.3 | 30.8 | 30.4 | 31.2 | 31.1 | 32.9 | 32.8 | 32.2 | 26.2 |
| Obesity (BMI⩾30 kg m−2), n (%) | 109 (25.6%) | 619 (64.8%) | 129 (62.9%) | 599 (50.9%) | 97 (46.2%) | 242 (53.3%) | 389 (54.4%) | 728 (73.8%) | 700 (73.1%) | 437 (64.4%) | 393 (99.5%) |
| SBP, mm Hg, mean | 158.8 | 155.5 | 159.1 | 156.1 | 157.1 | 156.3 | 156.5 | 156.3 | 156.3 | 156.1 | 157.1 |
| DBP, mm Hg, mean | 99.3 | 99.7 | 99.3 | 99.6 | 99.2 | 99.9 | 99.4 | 99.5 | 99.5 | 99.5 | 99.6 |
Abbreviations: BMI, body mass index; CV, cardiovascular; DBP, diastolic blood pressure; eGFR, estimated glomerular filtration rate; LDL, low-density lipoprotein; SBP, systolic blood pressure; T2DM, type 2 diabetes mellitus.