Table 4. Differences in CsA clearance, volume of distribution and half-life^a.

	Kidney Tx		Heart Tx	Healthy controls
	Adults	Children	Adults	Adults
Clearance (ml/min/kg)	5.7 (0.6–23.9)	11.8 (9.8–15.5)	4.0 (2.1–5.39)	3.9 (2.8–4.2)
Volume of distribution (l/kg)	4.5±3.6	4.7±1.5	1.3±0.2	1.2±0.2
Plasma half-life (h)	10.7 (4.3–53.4)	7.3 (6.11–16.6)	6.4 (5.2–9.3)	6.3 (4.7–9.5)

Abbreviations: CsA, cyclosporin A; Tx, transplantation.

^aIn relation to age, health and transplantation procedure according to Ptachcinski et al.⁵