Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Dec 12;1(1):6–16. doi: 10.1016/j.jcmgh.2014.11.006

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2015 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).

PMC Copyright notice

Microbiota and innate immune mechanisms regulate a proinflammatory microenvironment promoting tumor growth. Possibly as the result of a defective intestinal barrier, microbial products activate innate immune cells or intestinal epithelial cells (IECs), perhaps via TLRs, which then create a proinflammatory microenvironment with subsequent activation of Th17 cells characterized by the transcription factor RAR-related orphan receptor γT (RORγt). Proinflammatory cytokines released by activated innate immune cells, intestinal epithelial cells, or Th17 cells contribute to tumor cell proliferation and survival.