Table-3.
Antioxidant and peroxidation parameters of liver in different groups of rats.
| Group | Control | APAP control | APAP+SLM | APAP+RTN |
|---|---|---|---|---|
| TBARS concentration (n moles of MDA released/mg protein) | 18.50±0.32 | 23.19±0.48* | 19.60±0.29* | 20.18±0.34* |
| GSH concentration (n moles/mg protein) | 7.52±0.16 | 3.68±0.16* | 5.56±0.17* | 5.86±0.11* |
| GPX activity (U/mg protein) | 20.6±0.27 | 17.38±0.27* | 19.78±0.28 | 18.82±0.33* |
| SOD activity (U/mg protein) | 10.83±0.23 | 7.23±0.19* | 8.23±0.16* | 8.16±0.15* |
| Catalase activity (U/mg protein) | 4.94±0.01 | 3.18±0.01* | 4.64±0.02* | 4.19±0.0* |
Values are mean±SE (n=6); one-way ANOVA (SPSS),
*
p<0.05 in relation to group 1 (Duncan’s multiple comparison test). APAP=Acetaminophen, SLM=Silymarin, RTN=Rutin, TBARS=Thiobarbituric acid reactive substances, MDA=Malondialdehyde, GSH=Reduced glutathione, GPx=Glutathione peroxidase, SOD=Super oxide dismutase, SE=Standard error, SPSS=Statistical Package for Social Sciences