Table-5.
Hematological parameters of different group of rats.
| Group | Control | APAP control | APAP+SLM | APAP+RTN |
|---|---|---|---|---|
| Total erythrocyte count (106/mm3) | ||||
| Day 4 | 8.34±0.16 | 6.32±0.09* | 6.34±0.12* | 6.43±0.09* |
| Day 15 | 8.46±0.18 | 6.23±0.16* | 8.13±0.13 | 7.84±0.10* |
| Total leukocyte count (103/mm3) | ||||
| Day 4 | 8.63±0.11 | 10.43±0.12* | 10.24±0.11* | 10.36±0.11* |
| Day 15 | 8.74±0.11 | 10.51±0.11* | 8.82±0.09 | 8.94±0.09 |
| Hemoglobin concentration (g/dl) | ||||
| Day 4 | 16.56±0.17 | 12.32±0.23* | 12.38±0.23* | 12.48±0.18* |
| Day 15 | 16.42±0.19 | 12.53±0.19* | 16.14±0.24 | 15.72±0.17* |
| Packed cell volume (%) | ||||
| Day 4 | 42.64±0.27 | 34.36±0.18* | 33.86±0.15* | 34.57±0.12* |
| Day 15 | 43.14±0.22 | 34.32±0.09* | 41.43±0.09* | 40.91±0.05* |
| Prothrombin time (s) | ||||
| Day 4 | 14.88±0.57 | 26.32±0.59* | 26.16±0.79* | 26.28±0.84* |
| Day 15 | 14.88±0.57 | 26.32±0.59* | 16.47±0.67 | 17.43±0.54* |
Values are mean±SE (n=6); one-way ANOVA (SPSS),
*
p<0.05 in relation to group 1 (Duncan’s multiple comparison test). APAP=Acetaminophen, SLM=Silymarin, RTN=Rutin, ATPase: Adenosine triphosphatase, SE=Standard error, SPSS=Statistical Package for Social Sciences