Figure 3.

Lymphocytic choriomeningitis virus (LCMV)-specific CD4⁺and CD8⁺T-cell responses in infected transthyretin-nucleoprotein (TTR-NP) mice. (A) Class I tetramer staining (NP_396–404 and GP_33–41) of CD8⁺ T cells from spleen and liver of TTR-NP and B6 mice at 8 and 55 days after infection with low-dose (200 plaque-forming units [pfu]) LCMV-WE. (B) Class II tetramer staining (IA^b NP_309–328, GP_66–77, GP_31–45) of CD4⁺ T cells from the spleen and liver of TTR-NP and B6 mice at 8 and 55 days after infection. Proportions of class I and II tetramer-positive CD8⁺ or CD4⁺ T cells among total CD8⁺ or CD4⁺ T cells are shown. (Representative data of two to three independent experiments are shown; n = 4 per group.) *P < .05, **P < .01, ***P < .001.