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. 2017 Feb 10;7:42279. doi: 10.1038/srep42279

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Copyright © 2017, The Author(s)

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Hca2 KO and WT mice were sacrificed 4 h following endotoxemia induction. (A) HE staining (original magnification, 400×, bar: 10 μM) and immunofluorescent staining by anti-F4/80 antibody (original magnification, 630×, bar: 10 μM) of liver sections from saline-, LPS- or LPS + niacin-treated WT and Hca2^−/− mice. (B) The number of macrophages isolated from the ascites of WT and Hca2^−/− mice (n = 10) and IL-6 in the ascites of WT and Hca2^−/− mice treated with saline, LPS, or LPS + niacin (n = 8–10). Error bars represent standard deviation of the means (*p < 0.05; **p < 0.01, ***p < 0.001, compared with the indicated group). (C) ERK1/2 activation in niacin-treated macrophages from WT, Hca2^+/− and Hca2^−/− mice.