Table 3. Cumulative effects of rs12979860 and ss469415590 on HCV clearance and SVR.

Variablesa	Spontaneous clearance			Response to treatment
	Chronic N(%)	Resolver N(%)	OR (95% CI)b	N-SVR N(%)	SVR N(%)	OR (95% CI)c
0	572 (71.9)	385 (83.7)	1.00	61 (48.8)	174 (73.5)	1.00
1	111 (14.0)	39 (8.5)	0.52 (0.35–0.77)	16 (12.8)	34 (14.3)	0.81 (0.39–1.65)
2	82 (10.3)	34 (7.4)	0.62 (0.40–0.94)	42 (33.6)	23 (9.7)	0.13 (0.07–0.25)
3–4	30 (3.8)	2 (0.4)	0.10 (0.02–0.42)	6 (4.8)	6 (2.5)	0.18 (0.05–0.65)
Trend			Pd < 0.001			Pd < 0.001
0	572 (71.9)	385 (83.7)	1.00	61 (48.8)	174 (73.5)	1.00
1–4	223 (28.1)	75 (16.3)	0.50 (0.37–0.67)	64 (51.2)	63 (26.5)	0.28 (0.17–0.46)

Abbreviation: N-SVR, non sustained virological response; SVR, sustained virological response.

^aVariables are numbers of combined unfavorable genotypes (rs12979860 T and ss469415590 ΔG).

^bLogistic regression analyses adjusted for age, gender, and viral genotype.

^cLogistic regression analyses adjusted for age, gender, HCV RNA and platelets.

^dP value of Cochran-Armitage’s trend test.