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NASH-induced liver injury is decreased in hepatocyte-specific caspase 8 knockout mice (caspase 8Δhepa). Wild-type mice and mice carrying a hepatocyte-specific deletion of caspase 8 were fed the FFC diet (a NASH-inducing diet high in saturated fats, fructose, and cholesterol) for 3 months, and serum alanine transaminase activity was measured. P value was calculated using unpaired two-tailed t test.
