Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Binding mode comparison. (A) Binding mode of compound 10 in PB1(5). (B) Superimposition of the binding modes of inhibitors 10–12 showing a high degree of similarity. The remaining conserved water molecule (W5) is highlighted. Hydrogen bonds are indicated by dotted lines. The surface of the acetyl-lysine binding pocket is shown as a transparent sphere. (C) Comparison of binding modes of 12 and 14. (D) Comparison of binding modes of 12 and the PB1/SMARCA inhibitor 2.
