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Mechanism of chronic hypoxic vasoconstriction in human pulmonary artery. ROS = reactive oxygen species, Rho A and Rho B are members of Rho GTPases family which is a family of G proteins. Chronic hypoxia induced Rho A and Rho b and ROS production that results in smooth muscle cell proliferation, vascular remodelling and ultimately pulmonary artery hypertension.
