Fig. 4. Microbiome dysbiosis in HIV-exposed, uninfected infants.
(A) Random forest classification scheme to identify taxa associated with HIV status. Bacterial taxa enriched in HIV-unexposed infants are represented on the left, with bacterial taxa enriched in HIV-exposed uninfected infants on the right. (B) Bayesian estimate of the proportion of microbes in the infant samples that came from the mother. (C) A relative maturity index was calculated for each experimental sample based on the relative stool microbiome age versus the age of the subject at collection. This was then plotted along with the normalized midline of the previously published reference cohort of healthy controls.
