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. 2017 Feb 10;19:27. doi: 10.1186/s13075-017-1233-0

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Schematic representation of the molecular complex formed by vascular endothelial growth factor (VEGF)-bound VEGF receptor-2 (VEGFR-2), transient receptor potential canonical-1 (TRPC-1) and soluble α-Klotho (sKl) on the surface of endothelial cells (ECs). This molecular complex regulates the influx of Ca²⁺ and the permeability of the plasma membrane contributing to the maintenance of EC integrity