Table 3.

Animal models of miscellaneous interventions

Author, year [reference]	Animal	N	Intervention	Variables studied	Results
Intervention period: Embryonic
Risma et al. 1997 [37]	Mouse	20	transgenic (bLHβ-CTP)	Sexual hormones Gonadotropin Ovary morphology	↑ E2, ↑ T ↑ LH ↑ cystic follicles
Shi et al. 2009 [38]	Rat	18	transgenic (JCR:LA-cp)	Sexual hormones Ovary morphology	↑ T = E2 ↑ cystic follicles ↑ atretic follicles
Devin et al. 2007 [39]	Mouse	39	transgenic (PAI-1)	Sexual hormones Ovary morphology	↑ T ↑ cystic follicles ↓ CL
Intervention period: Puberty
Kafali et al. 2004 [40]	Rat	34	Letrozole 21 days	Sexual hormones Gonadotropin Ovary morphology	↑ T, ↓E2, ↑ LH, ↑ cystic follicles ↓ CL
Kang et al. 2015 [47]	Sprague–Dawley Rat		light exposition During 112 days	Sexual hormones Ovary morphology	↑ T ↑ cystic follicles ↑ atretic follicles
Intervention period: Adult
Bernuci et al. 2008 [42]	Rat	17	Chronic cold stress + LC lesion 60 days	Sexual hormones Ovary morphology	↑ T ↑ E2, = LH = FSH ↑ cystic follicles ↓ ovulation
Park and Choi, 2012 [43]	Mouse	15	D-galactose 45 days	Sexual hormone Ovarian morphology	↑ T ↑ cystic follicles
Ota, et al. 1987 [44]	Rat	33	hCG 80 days	Sexual hormones Gonadotropin Ovary morphology	= T ↑ E2 = LH = FSH ↑ cystic follicles
Baldissera, et al. 1991 [41]	Rat	15	Light exposure 74 days	Ovary morphology Gonadotropin	↑ cystic follicles ↓ CL = LH = FSH
Lagace &Nachtigal, 2003 [45]	Rat	22	Valproic acid 30 days	Sexual hormones Ovary morphology	= E2 = T ↑ replace cysts by cystic follicles
Radavelli- Bagatini et al. 2011 [46]	Mouse	45	Genetic	Sexual hormones Gonadotropin Ovary morphology	↓ T ↑ E2 ↓ LH ↓ CL, ↑ replace cysts by cystic follicles, ↑ atretic follicles
Li et al. 2016 [48]	Rat	10	Letrozole	Sexual hormones Gonadotropin Ovary morphology	↑ T, ↓ E2 ↑ LH, ↑ FSH ↑ cystic follicles

T testosterone, E2 estradiol, LH luteinizing hormone, FSH follicle-stimulating hormone, CL corpus luteum; ↑: increase; ↓ decrease; = equal