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. 2015 Jun 17;1(5):516–534. doi: 10.1016/j.jcmgh.2015.06.009

Figure 6.

Figure 6

Circulating tumor DNA (ctDNA) dynamics after undergoing transcatheter arterial chemoembolization (TACE). (A) Serum ctDNA levels at 1, 4, and 6 days after TACE are shown as a solid line, and serum aminotransferase (AST) and alanine aminotransferase (ALT) levels are shown as dotted lines. The x-axis shows the number of days after TACE. The y-axis on the left indicates the fold change of serum ctDNA levels compared with that before TACE, and the y-axis on the right indicates serum AST, ALT, AFP (α-fetoprotein), and des-γ-carboxy prothrombin (DCP) levels. The ctDNA levels of cases 2 and 3 increased 5- and 10-fold compared with before TACE, respectively. The ctDNA levels peaked 4 days after TACE was performed. (B) The ctDNA became detectable 4 days after TACE (S2) in two of three patients (cases H8 and H9) who were negative for ctDNA before TACE (S1). DNA extracted from cancer tissue samples was used as a positive control (C), and DNA extracted from blood cells were used as a negative control (B).