Table 1. Antibacterial activity of 430D-F5 on members of the skin microflora.
| Species | Strain | MIC | 430D-F5 | Antibiotic Controls* |
|||
|---|---|---|---|---|---|---|---|
| Amp | Clin | Erm | Van | ||||
| Corynebacterium amycolatum | SK46 | MIC50 | ND (512) | 0.0625 | — | 0.00781 | 0.5 |
| MIC90 | ND (512) | 2 | — | 2 | 2 | ||
| Corynebacterium striatum | FS-1 | MIC50 | ND (512) | ND (16) | — | 1 | 0.5 |
| MIC90 | ND (512) | ND (16) | — | 2 | 0.5 | ||
| Micrococcus luteus | SK58 | MIC50 | 64 | 0.125 | 0.125 | 0.0625 | 0.25 |
| MIC90 | 128 | 0.125 | 0.5 | 0.0625 | 0.25 | ||
| Propionibacterium acnes | HL005PA2; HM-493 | MIC50 | 16 | — | 0.125 | 0.125 | — |
| MIC90 | 256 | — | 0.125 | 0.5 | — | ||
| Staphylococcus epidermidis | NIHLM001; HM896 | MIC50 | 64 | 0.03125 | — | — | 1 |
| MIC90 | ND (512) | 0.0625 | — | NT | 1 | ||
| Staphylococcus haemolyticus | NRS116 | MIC50 | 64 | ND (32) | — | ND (32) | 1 |
| MIC90 | ND (512) | ND (32 | — | ND (32) | 2 | ||
| Staphylococcus warneri | SK66 | MIC50 | 64 | 0.0625 | — | — | 0.5 |
| MIC90 | ND (512) | 0.0625 | – | — | 1 | ||
| Streptococcus mitis | F0392 | MIC50 | 64 | 0.03125 | — | 0.00781 | 0.5 |
| MIC90 | ND (512) | 0.0625 | — | 0.03125 | 0.5 | ||
| Streptococcus pyogenes | MGAS15252 | MIC50 | ND (512) | 0.0156 | 0.125 | 0.0625 | — |
| MIC90 | ND (512) | 0.0313 | 0.125 | 0.0625 | — | ||
430D-F5 is nontoxic to several members of the skin microflora at the concentrations required for quorum sensing inhibition in S. aureus, but does inhibit growth of P. acnes.
*Amp: ampicillin; Clin: clindamycin; Erm: erythromycin; Van: vancomycin. —: not tested. ND: MIC not detected (max. concentration tested).