Table 2. Association of PGRS (MDD, SCZ or BP) at p ≤ 0.5 with gFA and gFA for association, projection and thalamic WM fibers.
| Including outliers (N = 816) |
Excluding outliers (N = 733) |
|||||||
|---|---|---|---|---|---|---|---|---|
| Beta: z ratio (S.D.) | t statistic | p | R2 | Beta: z ratio (S.D.) | t statistic | p | R2 | |
| MDD-PGRS | ||||||||
| gFA | 0.017 (0.036) | 0.476 | 0.634 | 0.030 | −0.011 (0.038) | −0.291 | 0.771 | 0.012 |
| gFA Association | 0.037 (0.036) | 1.026 | 0.305 | 0.139 | 0.011 (0.039) | 0.296 | 0.767 | 0.013 |
| gFA Projection | −0.020 (0.036) | −0.560 | 0.576 | 0.041 | −0.049 (0.038) | −1.297 | 0.195 | 0.244 |
| gFA Thalamic | 0.002 (0.037) | −0.043 | 0.966 | 0.000 | −0.025 (0.039) | −0.650 | 0.516 | 0.063 |
| SCZ-PGRS | ||||||||
| gFA | −0.028 (0.036) | −0.768 | 0.443 | 0.078 | −0.048 (0.039) | −1.237 | 0.216 | 0.230 |
| gFA Association | −0.020 (0.036) | −0.559 | 0.576 | 0.041 | −0.040 (0.039) | −1.034 | 0.302 | 0.161 |
| gFA Projection | −0.034 (0.036) | −0.947 | 0.344 | 0.116 | −0.036 (0.038) | −0.947 | 0.344 | 0.132 |
| gFA Thalamic | −0.032 (0.037) | 0.885 | 0.376 | 0.105 | −0.059 (0.039) | −1.521 | 0.129 | 0.348 |
| BP-PGRS | ||||||||
| gFA | −0.013 (0.036) | −0.367 | 0.714 | 0.017 | −0.014 (0.038) | −0.370 | 0.711 | 0.019 |
| gFA Association | −0.016 (0.036) | −0.442 | 0.659 | 0.025 | −0.017 (0.038) | −0.445 | 0.657 | 0.028 |
| gFA Projection | −0.023 (0.035) | −0.665 | 0.506 | 0.055 | −0.014 (0.037) | −0.369 | 0.712 | 0.019 |
| gFA Thalamic | −0.000 (0.036) | 0.0223 | 0.982 | 0.000 | −0.008 (0.038) | −0.214 | 0.831 | 0.008 |
FA: fractional anisotropy, WM: white matter, g: general component, MDD: major depressive disorder, SCZ: schizophrenia, BP: bipolar disorder, PGRS: polygenic risk scores, S.D.: standard deviation. Controlled for age, age2 and gender, genotype batch and array, and 15 MDS components. R2 = estimate of variance explained by PGRS in %.