Table 2.
Echocardiographic findings by SCT status in African Americans from ARIC (examination 5) and JHS (examination 1)
| Echocardiographic parameter | ARIC | JHS | ||||
|---|---|---|---|---|---|---|
| HbAA, n = 1221 | HbAS, n = 86 | P | HbAA, n = 1956 | HbAS, n = 177 | P | |
| Age | 76.0 ± 5.0 | 75.0 ± 5.0 | .26 | 50.2 ± 11.9 | 50.4 ± 12.3 | .83 |
| LV end-diastolic dimension, cm | 4.33 ± 0.54 | 4.27 ± 0.49 | .33 | 4.86 ± 0.44 | 4.86 ± 0.48 | .81 |
| LV relative wall thickness | 0.44 ± 0.09 | 0.45 ± 0.07 | .66 | 0.35 ± 0.08 | 0.35 ± 0.07 | .86 |
| LV mass indexed to height2.7 | 38.5 ± 11.8 | 36.7 ± 10.4 | .18 | 35.1 ± 10.4 | 35.1 ± 10.0 | .97 |
| LV ejection fraction, % | 64 ± 7 | 64 ± 7 | .94 | 61 ± 7 | 61 ± 7 | .83 |
| RV fractional area change, % | 52 ± 0.1 | 53 ± 0.1 | .52 | — | — | — |
| RV end-diastolic area, cm2 | 19.6 ± 5.3 | 20.5 ± 6.1 | .19 | — | — | — |
| Left atrial volume, mL | 50 ± 17 | 51 ± 19 | .58 | — | — | — |
| Tricuspid regurgitant velocity, m/s | 2.4 ± 0.3 | 2.4 ± 0.4 | .56 | 2.2 ± 0.7 | 2.1 ± 0.6 | .14 |
| Adverse remodeling, n (%) | 703 (58) | 54 (63) | .36 | — | — | — |
| Diastolic dysfunction, n (%) | 621 (52) | 39 (48) | .91 | — | — | — |
HbAA, normal hemoglobin genotype.