Scheme 3.
Synthesis of mannosazide building block 18. Reagents and conditions: (a) TBSCl, imidazole, DCM, 0 °C to rt, 85%; (b) NIS, TfOH, HO(CH2)5NBnCbz, CH2Cl2, −20 °C, 61%; (c) TBAF, THF, 0 °C, 80%.
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