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IncRNA-HIT and Hottip function in regulating Hoxa gene expression. (A) IncRNA-HIT binds to the p100/CBP complex and maintains H3K27ac marks at HoxA genes, resulting in gene activation (103). (B) Hottip acts in cis by recruiting the WDR5/MLL histone methyltransferase complex to the Hoxa genes, resulting in gene activation by establishing H3K4me3 marks (31).
