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Different mechanisms of H19 in osteogenesis. (A) H19 is processed into miR-675, which targets TGFB1 for degradation (135). (B) H19 acts as a sponge to sequester miR-141 and miR-22 away from their targets, thus leading to an upregulation of targeted mRNAs that may be required for osteoblast differentiation (134).
