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MALAT-1 function in osteosarcoma. (A) MALAT-1 IncRNA is not polyadenylated, but instead contains a triple helical domain at its 3ˊ end that protects it from degradation (180). (B) MALAT-1 binds to SFPQ in nuclear speckles. This sequestration prevents the formation of the SFPQ/PTBP2 complex. Subsequently, unbound PTBP2 can induce tumor growth by increasing cellular proliferation and migration (185).
