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. Author manuscript; available in PMC: 2018 Jan 3.
Published in final edited form as: Circulation. 2016 Nov 4;135(1):73–88. doi: 10.1161/CIRCULATIONAHA.116.022281

Figure 6.

Figure 6

Deletion of β2AR and β-arrestin2 prevents PDE4D induction in hearts of HFD mice. a) Deletion of β2AR prevented HFD-induced activation of ERK (T202/Y204) and Akt (S473), and PDE4D induction in mouse hearts (n=12). b) Deletion of β2AR normalizes PKA phosphorylation of PLB (S16) and TnI (S23/24), the ratio of serca2/PLB in mouse hearts and attenuates the induction of GRK2 (n=12). c) Deletion of β-arrestin2 prevents HFD-induced activation of ERK and Akt, and PDE4D induction in mouse hearts (n=12). d) Deletion of β-arrestin2 normalizes PKA phosphorylation of PLB (S16) and TnI (S23/24), the ratio of serca2/PLB in mouse hearts and prevents the induction of GRK2 (n=12). * p< 0.05 and ** p < 0.01 by one-way ANOVA followed by post hoc Tukey's test. &&&p< 0.001 by two-way ANOVA followed by post hoc Tukey's test.