Fig.3.

Changes in neural network connectivity after stroke. (A) Schematic representation of a neural network in human brain before (left), with nodes and edges in blue, and after stroke (right), illustrating global disconnection (red dotted edges) and reorganization (green edges) as a result of a focal stroke lesion (black area). (B) Diffusion tensor imaging-based fiber tractography maps of control (left) and 10-weeks post-stroke rat brain (right), showing altered fiber pathway patterns in perilesional white matter chronically after stroke. Stroke was induced by 90-min intraluminal occlusion of the right middle cerebral artery in adult male Sprague Dawley rats. High angular (120 directions) and spatial resolution (0.2 mm isotropic voxels) diffusion-weighted MRI data were acquired post mortem on a 9.4 T animal MRI scanner (total scan time: 26 h). MrTrix3^® software (http://www.mrtrix.org/) was used for diffusion-based tractography. Courtesy of Michel Sinke and Willem Otte.