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The 26S/20S proteasome structure and function. Top: Ubiquitin- and ATP-dependent protein degradation of substrates via the 26S proteasome. The 26S proteasome can also degrade proteins in an ubiquitin-independent manner (not shown). Bottom: Ubiquitin- and ATP-independent protein degradation of natively unfolded or damaged and partly unfolded substrates via the 20S proteasome. Inset shows the structural composition of the 26S proteasome. ATP adenosine triphosphate.
