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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Angew Chem Int Ed Engl. 2017 Jan 3;56(6):1506–1509. doi: 10.1002/anie.201610580

Table 1.

Screening of Ligands for C(sp3)–H Arylation.[a,b]

graphic file with name nihms-846244-f0004.jpg
a

Experiments were performed with substrate 1 (0.1 mmol), Pd(OAc)2 (10 mol%), AgOAc (0.2 mmol), Ar–I (0.25 mmol), Na2HPO4·7H2O (0.15 mmol), Ligand (20 mol%), HFIP (1.0 mL), 100 °C, 24 h.

b

Determined by 1H NMR analysis ofthe crude product using CH2Br2 as an internal standard.

[c] HFIP (2.0 mL).

[d] L15 (10 mol%)+L8 (10 mol%).

[e] Conditions: substrate (0.1 mmol), Pd(OAc)2 (10 mol%), Ag2CO3 (0.2 mmol), Ar–I (0.25 mmol), ligand (10 mol%), K2HPO4 (0.1 mmol), HFIP (1.0 mL), 100 °C, 24 h.

[f] Ar = 3,5-di-t-butylphenyl