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. Author manuscript; available in PMC: 2018 Feb 1.
Published in final edited form as: Angew Chem Int Ed Engl. 2017 Jan 3;56(6):1506–1509. doi: 10.1002/anie.201610580

Table 3.

Arylation of Other Amino Acids and Carboxylic Acids.[a]

graphic file with name nihms-846244-f0008.jpg
[a]

Isolated yields are shown based on corresponding methyl ester.

[b] Conditions: substrate (0.1 mmol), Pd(OAc)2 (10 mol %), AgOAc (0.2 mmol), Ar–I (0.25 mmol), Na2HPO4·7H2O (0.15 mmol), L15 (20 mol%), HFIP (1.0 mL), 100 °C, 24 h.

[c] Conditions: substrate (0.1 mmol), Pd(OAc)2 (10 mol%), AgOAc (0.2 mmol), Ar–I (0.25 mmol), Na2HPO4·7H2O (0.15 mmol), L18 (12 mol%), HFIP (1.0 mL), 100 °C, 24 h.

[d] Conditions: substrate (0.1 mmol), Pd(OAc)2 (10 mol%), Ag2CO3 (0.2 mmol), Ar–I (0.25 mmol), L18 (12 mol%), K2HPO4 (0.1 mmol), HFIP (1.0 mL), 100 °C, 24 h.

[e] Conditions: substrate (0.1 mmol), Pd(OAc)2 (10 mol%), AgOAc (0.2 mmol), Ar–I (0.25 mmol), Na2HPO4·7H2O (0.15 mmol), L8 (20 mol%), HFIP (1.0 mL), 100 °C, 24 h.