Table 1.
Cross Sectional Associations of Demographic and Clinical Variables with Left Atrial Volume at DHS-2
| Variable | Q1 | Q2 | Q3 | Q4 | P trend |
|---|---|---|---|---|---|
| LA volume/BSA (mL/m2) |
22.4 [19.5, 24.6] |
30.0 [28.0, 31.2] |
36.1 [34.7, 37.9] |
46.0 [42.6, 51.4] |
|
| Age (years) | 50 [44, 58] | 49 [41, 58] | 49 [42, 56] | 50 [44, 58] | 0.93 |
| Male Sex (%) | 41.1 | 36.3 | 42.1 | 43.2 | 0.44 |
| Race/Ethnicity (%) | |||||
| Black | 36.3 | 38.9 | 50.0 | 53.7 | <.0001 |
| White | 46.3 | 48.9 | 33.2 | 26.8 | <.0001 |
| Hispanic | 12.6 | 9.5 | 15.3 | 18.9 | 0.028 |
| Other | 4.7 | 2.6 | 1.6 | 0.5 | 0.006 |
| Diabetes (%) | 14.7 | 11.6 | 13.2 | 10.5 | 0.30 |
| Hypertension (%) | 37.9 | 37.9 | 42.1 | 48.9 | 0.019 |
| Systolic Blood Pressure (mmHg) |
125 [114, 136] | 124 [115, 137] | 127 [117, 140] |
131 [120, 144] | <.0001 |
| Diastolic Blood Pressure (mmHg) |
79 [72, 85] | 79 [74, 85] | 79 [74, 85] | 79 [73, 85] | 0.86 |
| Smoking (%) | 21.9 | 19.5 | 20.3 | 18.8 | 0.52 |
| BMI (kg/m2) | 28.4 [25.2, 31.6] |
28.0 [24.6, 32.4] |
29.5 [25.3, 33.2] |
30.1 [26.4, 35.1] |
<0.001 |
| Waist Circumference (cm) |
91.4 [81.3, 99.1] |
92.7 [83.8, 101.3] |
92.4 [83.8, 102.9] |
96.2 [86.4, 105.4] |
0.008 |
| LV Mass/ BSA (g/m2) |
58.6 [51.1, 68.9] |
58.2 [51.2, 67.6] |
63.3 [53.4, 73.0] |
68.7 [56.6, 79.2] |
<.0001 |
| LVEDV/BSA (mL/m2) |
55.0 [47.9, 61.6] |
56.5 [50.4, 65.5] |
61.7 [54.6, 68.6] |
65.2 [59.0, 72.5] |
<.0001 |
| LV Wall Thickness (mm) |
10.7 [9.8, 11.9] |
10.6 [9.9, 12.0] |
11.0 [10.0, 12.1] |
11.3 [10.4, 12.6] |
<.0001 |
| LV Ejection Fraction (%) |
69.8 [65.5, 74.1] |
69.4 [64.9, 73.8] |
69.5 [64.4, 73.0] |
69.6 [66.2, 74.4] |
0.98 |
| NT-Pro-BNP (pg/mL) |
34.3 [18.9, 63.7] |
37.9 [23.4, 67.8] |
42.2 [24.0, 73.6] |
51.4 [29.6, 90.4] |
<.0001 |
| hsCRP (mg/L) | 2.6 [1.1, 5.6] | 2.0 [1, 4.3] | 2.3 [1, 5.1] | 2.4 [1.1, 4.6] | 0.76 |
| hs-cTnT (ng/L) | 4.7 [1.5, 6.9] | 4.4 [1.5, 8.0] | 4.7 [1.5, 7.4] | 4.5 [1.5, 8.0] | 0.95 |
DHS: Dallas Heart Study; LA: left atrial; LV=left ventricular; EDV=end diastolic volume; BMI=body mass index; BSA = body surface area; NT-Pro-BNP – N-terminal pro-brain natriuretic peptide; hs-CRP=high sensitivity C-Reactive Protein; GFR=glomerular filtration rate.
Left atrial size was indexed to body surface area