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. Author manuscript; available in PMC: 2017 Feb 10.
Published in final edited form as: Mol Cancer Ther. 2016 Nov 9;16(1):25–34. doi: 10.1158/1535-7163.MCT-16-0239

Figure 3.

Figure 3

A, Experimental schedule: NSG mice bearing HCT116 p53−/− tumor xenografts. N = 9 control, 9 AZD6738, 13 radiation only, 9 radiation + AZD6738. B, Tumor growth curves, normalized to the first tumor measurement after treatment began. Error bars, SEM. C, Survival probabilities, P value: difference between radiation and radiation + AZD6738. D, Western analysis of xenograft samples for p(S345)Chk1 after irradiation or mock irradiation in the presence or absence of 75 mg/kg AZD6738 administered 2 hours prior to radiation treatment, samples collected 2 hours after radiation.

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