Extended Data Figure 5. IL-22-Fc improves resistance to C. rodentium infection in R26^Cyp1a1 mice.

Mice of indicated genotypes were infected orally with ~2x10⁹ C. rodentium and killed 7 days after infection or monitored for survival. a, C. rodentium burdens in the colon and caecum. Bars are the median and each symbol represents an individual mouse. b, Colon sections stained for E-Cadherin (green), C. rodentium (red) and DAPI (blue). Scale bars represent 100μm. c, Survival plot (WT: n=4, R26^Cyp1a1 +Ctrl Ig: n=6, R26^Cyp1a1 +IL-22Fc: n=5).

Results are representative of three independent experiments.

NS = not significant, **P < 0.01, ***P < 0.001, as calculated by one-way ANOVA with Tukey post-test.