Table 4. Differences in responses of MSHR5848 variants to PM substrates.

A: Smooth
PM Plate	No. wells	Substrate	Class or Mode of Action
1	6	L-Threonine	C-Source
		Citric Acid	C-Source
		L-Asparagine	C-Source
		D-Glucose-1-Phosphate	C-Source
		D-Galactonic Acid-g-Lactone	C-Source
		N-Acetyl-D-Glucosamine	C-Source
2	3	L-Pyroglutamic Acid	C-Source
		Putrescine	C-Source
		D,L Carnitine	C-Source
10	2	pH 4.5	pH, growth at 4.5
		pH 4.5 + L-Methionine	pH, decarboxylase
13	1	Thallium (I) acetate	toxic cation
14	1	Cadmium Chloride	transport, toxic cation
15	1	Guanidine hydrochloride	membrane, chaotropic agent
16	3	Chloroxylenol	Fungicide, disinfectant
		Dichlofluanid	fungicide, phenylsulphamide
		Potassium Tellurite	transport, toxic anion
17	1	Aminotriazole	histidine biosynthesis, catalase
18	3	Ketoprofen	anti-capsule
		2-Phenylphenol	DNA intercalator
		Tinidazole	Mutagen, nitroimidazole
19	2	Umbelliferone	DNA intercalator
		Thioglycerol	reducing agent, thiol, adenosyl methionine antagonist
20	2	Captan	fungicide, carbamate, multisite
		8-Hydroxyquinoline	chelator, lipophilic
B: Rough
PM Plate	No. wells	Substrate	Class or Mode of Action
4	15	L-Methionine	S-Source
		N-acetyl-D,L Methionine	S-Source
		L-Cysteine	S-Source
		D-Methionine	S-Source
		L-Methionine Sulfoxide	S-Source
		L-Cysteinyl-Glycine	S-Source
		Glycyl-L-Methionine	S-Source
		Glutathione	S-Source
		Cystathionine	S-Source
		Lanthionine	S-Source
		D-Cysteine	S-Source
		Thiophosphate	S-Source
		Dithiophosphate	S-Source
		L-Djenkolic Acid	S-Source
		D,L-Ethionine	S-Source
7	5	tryptophan-Asp	N-source, dipeptide
		tryptophan-tyrosine	N-source, dipeptide
		tryptophan-phenylalanine	N-source, dipeptide
		phenylalanine-tryptophan	N-source, dipeptide
		phenylalanine-Serine	N-source, dipeptide
15	1	Domiphen bromide	membrane, detergent, cationic, fungicide
17	1	Phenylarsine Oxide	tyrosine phosphatase
19	3	Iodonitro Tetrazolium Violet	respiration
		Coumarin	DNA intercalator
		Harmane	imidazoline binding sites, agonist