Table 5. Cytotoxicity of the Smooth and Rough variants of Bp MSHR5848 in J774.A1 macrophage cultures.
| MNGC or necrotic | MNGC | |||
|---|---|---|---|---|
| Variant | % cell loss | % cells dead (TB)a | cells (% of total)b | nuclei (%)b |
| Smooth | 75 | 75 | 17.7 | 67.2 |
| Rough | 15 | 12.5 | 3.6 | 14.5 |
aTB: determined by trypan blue staining and does not include unstained necrotic (dead) cells.
bThe extensive cell loss induced by the Smooth infection minimized the significance of these values.