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. 2014 Mar 4;2(1):85–106. doi: 10.3390/proteomes2010085

Figure 5.

Figure 5

Regulation of jasmonate-responsive gene expression by MYC2 and JAZ proteins. In absence of JA-Ileu, JAZ protein interacts through its N-terminal domain with MYC2, causing the transcription factor to remain inactive. When the JA-Ileu level increases, JA-Ileu binds to Jas domain of JAZ protein and promotes interaction of JAZ protein with COI1 leading to the formation of the SCFCOI1 complex. The SCFCOI1 complex causes ubiquitination of JAZ protein in its Jas domain and the protein is degraded by the 26S proteasome complex. MYC2 is released and promotes transcription of target genes.